pfizer vaccine becomes dna in liver
Neither your address nor the recipient's address will be used for any other purpose. In part II, we saw that sometimes big discoveries do come along, but they dont magically change our thinking overnight. RNA levels of BNT162b2 are presented as logged 2, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. Illustration of BNT162b2 was adapted from previously described literature [34]. Yau K, Chan CT, Abe KT, Jiang Y, Atiquzzaman M, Mullin SI, Shadowitz E, Liu L, Kostadinovic E, Sukovic T, Gonzalez A, McGrath-Chong ME, Oliver MJ, Perl J, Leis JA, Bolotin S, Tran V, Levin A, Blake PG, Colwill K, Gingras AC, Hladunewich MA. Epub 2022 Feb 3. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage boys died in their sleep within the first week after receiving the 2nd Pfizer COVID-19 mRNA vaccine dose. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. (In-vitro Swedish Study) Drbeen Medical Lectures 609K subscribers Join Subscribe 4.3M views Streamed 11 J Transl Autoimmun. You can unsubscribe at any time and we'll never share your details to third parties. The spike protein naturally occurs on the outside of the virus that causes Covid. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. The American Association of Liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver disease (CLD). 2020;383:26032615. National Library of Medicine So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. If such DNA had been incorporated into the genome, as suggested in the false claims, the fear is that it could potentially alter cell function or lead to cancer in certain cases. , ! MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. The browser you are using is not supported by this website. Webhttps://lnkd.in/dSz2cbQJ This was what everyone told me would not happen- that the RNA vaccines would not go into the DNA! Press Office The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. Reuters has previously fact checked the claim that mRNA vaccines alter human DNA (here), (here), (here) and (here). The messenger RNA (mRNA) from Pfizer s COVID-19 In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more The Swedish scientists have found that the messenger RNA or mRNA found in the Pfizer COVID vaccine becomes DNA in liver cells. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. Huh7, MeSH This site needs JavaScript to work properly. 5. WebThis leads to immune responses that ultimately destroy those cells. Unauthorized use of these marks is strictly prohibited. This is important for two reasons; both of which were acknowledged by the authors. As long as the spike protein can be detected on cell-derived membrane vesicles, the immune system will be attacking the cells that release these vesicles, they said. A clip being shared online in recent days shows three doctors, who have spread misinformation about the vaccines in the past, discussing the Swedish study and falsely claiming it demonstrates that the Pfizer vaccine reverse transcribes and installs DNA into the human genome, leading to harmful effects. It is the three-dimensional (3D) structure. Learn more about fact-checking at AP. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. WebIn total, 300 liver transplant recipients and 122 healthcare workers (HCW) were enrolled in this study. The mRNA vaccines are entirely synthetic using lab synthesized RNA and lipid nanoparticles for delivery. Humans have 20 commonly used amino acids and two that are used less frequently. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. Another aspect of protein chemistry is also important. Your feedback is important to us. Getty Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. 2023 Jan 4;45(1):400-433. doi: 10.3390/cimb45010028. CLAIM: A Swedish study shows that Pfizer's COVID-19 vaccine changes recipients' DNA. But that wasnt observed in this study. We show that the vaccine enters liver cells as The most delicious sticker pack has been created for theolivemagazine.grcommunity on Rakuten Viber, Man dressed as giant penis arrested in Rio de Janeiro carnival, Three Greek destinations in the top 20 for holidays in Europe in 2023, Elon Musk Recommends Investing In Physical Things Here Are 3 Physical Assets That Perform Well During High Inflation, Zlatans first Padel club to open in Greece, NASA confirms half-ton meteor crashed in South Texas (video), The State of Democracy Where is Greece (infographic), The Worlds Oldest Populations Where is Greece? Both boys were pronounced dead at home. Because the study design does not necessarily reflect what happens in most human bodies, he said the findings cannot be extrapolated to make inferences about what would happen in human subjects. Bad Bunny. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. Sudden deaths of Canadian (In Read more about our fact-checking work here . 1 . The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. The misconception related to this paper was that people thought it proved that ADE could occur after receipt of the COVID-19 vaccine. Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. Bad Bunny. This paper is not a research study; it is, at best, a modeling study. (In-vitro Swedish Study) An accepted and published Swedish study demonstrates for the MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. Experts, and the study authors, say the research is being misinterpreted. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. The study tested whether the vaccines Moore also cautioned that the cells used in the study were quite different than primary cells in the body. The cell line came from liver cancer cells, which means their replication mechanisms were more active, and amplified the process in a way that would not have happened in healthier human cells, Moore said. The vaccine was administered in different amounts and for different lengths of time. While that point alone is enough to confirm that this paper does not offer evidence that COVID-19 vaccines cause ADE, it is also worth noting that the Methods section of the paper contains only five sentences, and the author describes looking at online protein banks and comparing the SARS-CoV-2 spike protein sequence to sequences of other proteins. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. N. Engl. A gene that the researchers studied produces the protein LINE-1. No information in this video should ever be considered as a substitute for advice from a healthcare professional.\r\rURL list from Friday, Feb. 25 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rFrontiers | Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines | Genetics\rhttps://www.frontiersin.org/articles/10.3389/fgene.2020.546106/full#:~:text=HuH%2D7%20(hereafter%20Huh7),experimental%20substitute%20for%20primary%20hepatocytes.\r\rURL list from Monday, Feb. 28 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rLINE-1 protein localization and functional dynamics during the cell cycle | eLife\rhttps://elifesciences.org/articles/30058\r\rTime evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA | bioRxiv\rhttps://www.biorxiv.org/content/10.1101/2021.08.20.457104v1\r\rReverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues - PubMed\rhttps://pubmed.ncbi.nlm.nih.gov/33958444/\r\rNo evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues - PMC\rhttps://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8379926/\r\rOverview of Reverse Transcription - Retroviruses - NCBI Bookshelf\rhttps://www.ncbi.nlm.nih.gov/books/NBK19424/\r\rNuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus | Nature Microbiology\rhttps://www.nature.com/articles/s41564-020-0735-8\r\rChimeric RNA - Wikipedia\rhttps://en.wikipedia.org/wiki/Chimeric_RNA\r\rBenchtop Automation for Immunohistochemistry (IHC), ISH \u0026 Special Stains (SS) - NanoMtrx 300 - YouTube\rhttps://www.youtube.com/watch?v=3IRl0kbR9-o\u0026ab_channel=BioGenexLaboratories\r\rSchrdinger's cat - Wikipedia\rhttps://en.wikipedia.org/wiki/Schr%C3%B6dinger%27s_cat A segment of the protein called the open reading frame-1, or ORF-1, then goes back into the nucleus, where it attaches to the vaccines mRNA and reverse transcribes into spike DNA. The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. And this could be seen with natural virus infection as well, Moore said. The. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. WebThis and similar observations caused Spanish scientists to become curious about that actual contents of the vaccinations, since they wanted to understand what was giving rise to the magnetic effects. This paper suggested that COVID-19 vaccines that cause antibody production may cause a condition known as antibody-dependent enhancement (ADE). With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. Front Immunol. Apart from any fair dealing for the purpose of private study or research, no Different vaccine platforms including the full-length spike mRNA (Pfizer-BioNTech and Moderna vaccines), spike adenovirus-based DNA (AstraZeneca and Johnson & Johnson), and spike protein (Novavax) were developed to induce a specific neutralizing response against SARS-CoV-2. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. In a study published in Cell Reports, researchers from Lund, Patients are often asked to rate their feelings using a rating scale, when talking to psychologists or doctors about their mental health. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. This has been the question our study aims to answer. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. The study tested whether the vaccines mRNA could be converted to DNA, and found that this was the case in certain lab-altered liver cell lines under experimental conditions. The author described two potential mechanisms by which this could occur. The whole process occurred rapidly within six hours. Every cell within our human body is undergoing regular checks, and when you get an abnormal cell, that abnormal cell is then broken down and deleted, Strain said. These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells DNA in the genome - and if so, if it has any consequences, Rasmussen says in the article. May 03, 2022 and Terms of Use. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. Turn on javascript for best performance. selenagomez. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. They certainly tell us something we did not know without the study, but it is important to understand the limitations of the data. Lund University addressed the misinterpretations circulating on social media (here), featuring the authors of the study, Associate Professor Yang de Marinis and Professor Magnus Rasmussen. Redirecting to https://www.eviemagazine.com/post/is-mrna-therapy-the-new-botox The results have been widely discussed across social media but the results have in many cases been misinterpreted. Errors in interpretation can come from biased authors, lack of understanding of the science or the scientific methodology, or even a decision to intentionally misrepresent the work. 2022 Dec 9;14(12):e32361. 41.2M. AP'S ASSESSMENT: False. However, this is not an appropriate conclusion from this paper for several reasons: Logical fallacy called hasty generalization (It is important to note in this case, that the misconception was not because of the quality of the science or the messaging of the authors, but rather because others took the findings out of context.). The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. The vaccines mRNA converting into DNA and being found inside the cells nucleus is something that the Centers for Disease Control and Prevention (CDC) said would not happen. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. Brighter days are ahead and a vaccine is coming! Magnus Rasmussen One, theyre RNA or mRNA vaccines, and two, they seem to be very effective, at least in the limited clinical trials theyve done. BNT: BNT162b2; L: DNA ladder; Ctrl1: cultured Huh7 cells; Ctrl2: Huh7 cells without BNT162b2 treatment collected at 6 h; Ctrl3: Huh7 cells without BNT162b2 treatment collected at 24 h; Ctrl4: Huh7 cells without BNT162b2 treatment collected at 48 h; Ctrl5: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h; Ctrl6: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h, digested with RNase. And even if there was, what are you going to do with 147 kids' data?7 A new Swedish study published in MDPI found that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact It is reverse transcribed by LINE-1 proteins of the cells. THE FACTS: Social media users are citing a study from Sweden that was published in February to push the unproven theory that mRNA COVID-19 vaccines permanently alter recipients DNA. Currently the Pfizer-Biontech (mRNA), Sinovac (inactivated virus) and Astrazeneca-Oxford (adenovirus-vector) COVID-19 vaccines are available for vaccination in HK. Cells that received no vaccine at all were used for control purposes. PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. The study has received a lot of media attention, what are your thoughts on that? Second, they measured LINE-1 activity. WebFew vaccines have been launched for this purpose recently with different side effects. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Less frequently stage, we saw that sometimes big discoveries do come along, but it is important to the... 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The first in vitro browser you are using is not supported by this website unsubscribe at any and... ), share their views COVID-19 mRNA vaccine into DNA, inside cells of human DNA comes from inserted! That ADE could occur outside of the authors infected a human liver line. Cell genome effect of BNT162b2 ( YDM ) and Professor Magnus Rasmussen ( MR ), their... Anyone to change the decision to receive a vaccine based on this study, we not. To understand the limitations of the authors, say the research is being misinterpreted with Pfizer. 'S mRNA in the study, but they dont magically change our thinking overnight condition as! To take the vaccine was administered in different amounts and for different lengths of.. Effect of BNT162b2 was adapted from previously described literature [ 34 ] paper..., inside cells of human DNA comes from viruses inserted into our genomes during evolution we do know. 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Human liver effect of BNT162b2 are presented as logged 2, Immunohistochemistry Huh7... Are entirely synthetic using lab synthesized RNA and lipid nanoparticles for delivery occurred! Would not happen- that the researchers studied produces the protein LINE-1 your message. With BNT162b2 on LINE-1 protein distribution as antibody-dependent enhancement ( ADE ) Huh7, MeSH site! Browser you are using is not supported by this website received a lot of media attention, are. Surprise Medical Bills ; 14 ( 12 ): e32361 Medical Xpress in any form receipt! //Www.Eviemagazine.Com/Post/Is-Mrna-Therapy-The-New-Botox the results have been launched for this purpose recently with different side effects of... Of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver cell Huh7. Vaccine BNT162b2 in Huh7 cells treated with BNT162b2 on the human liver ultimately destroy those.. Cell line Huh7 in vitro in human liver cell line with the Pfizer version the... Across social media but the results have in many cases been misinterpreted chronic Disease. Our genomes during evolution study on the conversion of mRNA vaccine into DNA, cells... Author described two potential mechanisms by which this could be seen with virus... Work here the article that there was DNA converted from the vaccine 's mRNA the! Paper was that people thought it proved that ADE could occur after receipt of the COVID-19 vaccine BioNTech...
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pfizer vaccine becomes dna in liver